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anticoagulant activities

" in MedChemExpress (MCE) Product Catalog:

24

Inhibitors & Agonists

5

Biochemical Assay Reagents

2

Peptides

3

Natural
Products

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N7671
    Euphorbetin

    		Others Cardiovascular Disease
    Euphorbetin exhibits anticoagulant activities .
    Euphorbetin
  • HY-139167
    7-Hydroxywarfarin

    Warfarin RC15

    		 Others Others
    7-Hydroxywarfarin is a Warfarin analog with anticoagulant activity .
    7-Hydroxywarfarin
  • HY-17378
    Dabigatran (ethyl ester)
    1 Publications Verification

    		 Thrombin Cardiovascular Disease
    Dabigatran ethyl ester is an emerging oral anticoagulant which is a direct inhibitor of thrombin activity.
    Dabigatran (ethyl ester)
  • HY-10777
    EMD 495235

    		Factor Xa Cardiovascular Disease
    EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC50 of 5.5 nM and a Ki of 6.8 nM. EMD 495235 shows anticoagulant activities .
    EMD 495235
  • HY-160067
    T18.3 aptamer sodium

    		Others Infection
    T18.3 aptamer sodium is an anticoagulant RNA aptamer targeting FV/Va and eliminates the interaction of FV/FVa with phospholipid membranes. T18.3 aptamer sodium exhibits clinically relevant anticoagulant activity in plasma and whole blood and acts synergistically with low molecular weight heparin. The anticoagulant activity of T18.3 aptamer sodium is effectively and rapidly reversed by protamine sulfate .
    T18.3 aptamer sodium
  • HY-N0228
    Scoparone
    4 Publications Verification

    		 Others Cardiovascular Disease Cancer
    Scoparone is isolated from Artemisia capillaris Thunb., has anticoagulant, vasorelaxant antioxidant, anti-inflammatory activities .
    Scoparone
  • HY-132179
    Fucoidan
    1 Publications Verification

    		 Glucosidase Cardiovascular Disease Metabolic Disease Cancer
    Fucoidan, a biologically active polysaccharide, is an efficient inhibitor of α-amylase and α-glucosidase. Anticoagulant, antitumor, antioxidant and antisteatotic activities .
    Fucoidan
  • HY-10269
    LY-517717

    		Factor Xa Cardiovascular Disease
    LY-517717 is a potent and orally active FXa inhibitor. LY-517717 shows antithrombotic and anticoagulant activity. LY-517717 has the potential for the research of venous thromboembolism after hip or knee replacement .
    LY-517717
  • HY-N1196
    Suberosin

    Suberosin, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB .
    Suberosin
  • HY-10277
    Odiparcil

    SB-424323

    		 Thrombin Cardiovascular Disease
    Odiparcil (SB-424323) is an orally active beta-d-thioxyloside analog with antithrombotic activity associated with a reduced risk of adverse bleeding events. Odiparcil (SB-424323) is indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II) .
    Odiparcil
  • HY-B0190S1
    Nafamostat formate salt-13C6

    		Ser/Thr Protease Apoptosis SARS-CoV Cardiovascular Disease
    Nafamostat formate salt- 13C6 is the 13C labeled Nafamostat[1]. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2[2][3][4][5].
    Nafamostat formate salt-13C6
  • HY-122704A
    Surfen dihydrochloride
    1 Publications Verification

    Aminoquincarbamide dihydrochloride

    		 FGFR HSV VEGFR Infection
    Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection .
    Surfen dihydrochloride
  • HY-149833
    ERRγ inverse agonist 2

    		Estrogen Receptor/ERR Infection Metabolic Disease
    ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities .
    ERRγ inverse agonist 2
  • HY-150682
    FXIa-IN-9

    		Factor Xa Cardiovascular Disease
    FXIa-IN-9 (compound 3f) is a potent and selective FXIa inhibitor. FXIa-IN-9 can bind with FXIa and form hydrogen bond (human FXIa Ki: 0.17 nM, rabbit FXIa Ki: 0.5 nM). FXIa-IN-9 also has anticoagulant activity, and can be used in the research of thromboembolic diseases such as atrial fibrillation, stroke, myocardial infarction, deep vein thrombosis, and pulmonary embolism .
    FXIa-IN-9
  • HY-109509
    Enoxaparin

    PK 10169; Enoxaparin sodium; Lovenox

    		 Factor Xa Thrombin SARS-CoV Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
    Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19 .
    Enoxaparin
  • HY-Y0682S
    EDTA-d12

    Ethylenediaminetetraacetic acid-d12

    		 Isotope-Labeled Compounds
    EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
    EDTA-d12
  • HY-Y0682S1
    Ethylenediaminetetraacetic acid-d16

    EDTA-d16

    		 Isotope-Labeled Compounds
    Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
    Ethylenediaminetetraacetic acid-d16
  • HY-Y0682
    Ethylenediaminetetraacetic acid
    Maximum Cited Publications
    8 Publications Verification

    EDTA

    		 Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease
    Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid
  • HY-W105700
    Ethylenediaminetetraacetic acid sodium hydrate
    5 Publications Verification

    EDTA sodium hydrate

    		 Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease
    Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid sodium hydrate
  • HY-B1009
    Ethylenediaminetetraacetic acid trisodium salt
    Maximum Cited Publications
    8 Publications Verification

    EDTA trisodium salt; Trisodium EDTA

    		 Ferroptosis Bacterial SOD Cardiovascular Disease Neurological Disease
    Ethylenediaminetetraacetic acid trisodium salt (EDTA trisodium salt; Trisodium EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid trisodium salt has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid trisodium salt decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid trisodium salt can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid trisodium salt
  • HY-Y0682B
    Ethylenediaminetetraacetic acid tetrasodium
    5 Publications Verification

    EDTA tetrasodium

    		 Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease
    Ethylenediaminetetraacetic acid (EDTA) tetrasodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid tetrasodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid tetrasodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid tetrasodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid tetrasodium can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid tetrasodium
  • HY-B0385
    Gabexate mesylate
    4 Publications Verification

    FOY

    		 Proteasome Factor Xa Inflammation/Immunology
    Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with Kis of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with Kis of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .
    Gabexate mesylate
  • HY-Y0682A
    Ethylenediaminetetraacetic acid disodium dihydrate
    5 Publications Verification

    EDTA disodium dihydrate

    		 Biochemical Assay Reagents Bacterial SOD Cardiovascular Disease Neurological Disease
    Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .
    Ethylenediaminetetraacetic acid disodium dihydrate
  • HY-P1956
    Human serum albumin
    1 Publications Verification

    HSA

    		 NF-κB NO Synthase Cardiovascular Disease Inflammation/Immunology
    Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO −) in the vascular wall, contributing to the reduction of blood pressure .
    Human serum albumin

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